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Description
K9 Advantix II Flea, Tick & Mosquito Treatment & Prevention for Large DogsK9 Advantix II Large Dog is the veterinarian recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult
K9 Advantix II Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die. Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia. That’s why K9 Advantix II Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh to use K9 Advantix II Large Dog. For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park. K9 Advantix II Large Dog is a trademark of Elanco or its affiliates.
Key Features
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K9 Advantix II treatment & prevention protects dogs from fleas, ticks, mosquitoes, biting flies and lice
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Kills fleas within 12 hours of application
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Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
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Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
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No prescription needed
Directions for Use
Use only on dogs. DO NOT USE ON CATS or other animals. Do not apply to dogs weighing less than 4 lbs. Remove applicator tube from the package. Use scissors and peel down foil. Hold applicator tube in an upright position. Pull cap off tube. Turn cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. The dog should be standing for easy application. Evenly apply entire contents of the tube along the top of the dog's back, from the shoulder down to the base of the tail. The number of spots depends on the size and weight of your dog (please refer to the product label). At each spot, part the hair until skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog’s eyes, or allow your dog to ingest this product.
Storage Instructions
Store in a cool, dry place inaccessible to children and pets. Protect from freezing.
Active Ingredients
Imidacloprid, Permethrin, Pyriproxyfen
Product Form
- Topical
Pet Size
- Large
Pet Lifestage
- 7 weeks and older
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.6 ★★★★★
Based on 30 reviews
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Product Reviews
★★★★★ 5
Leave a toy for the dog when going to work, and no housebreaking when coming back
Color: Purple-Blue, Size: 2pcs
The dog is quite clingy. Every time it sees me put on my shoes to go out, it gets nervous. Since having this bear around, when it goes out, its attention is all on the toys, and when it comes back home, its mood has become much more stable.
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Reviewed in the United States on May 26, 2026
★★★★★ 5
Keeps my dog busy and actually holds up
This jigsaw-style dog toy has been a game changer for keeping my dog entertained. The design is super versatile—you can spread peanut butter (or yogurt, wet food, etc.) into the grooves, and it keeps them busy licking for a long time.
What I like most is that it’s not just a lick mat—it’s also a durable chew toy. The material feels strong and holds up really well, even with a dog that usually destroys toys pretty quickly. Toys made from rubber or similar materials tend to last longer and are safer for chewing compared to softer options.
The grooves and compartments make it a little more challenging (in a good way), so it takes my dog longer to get through the treats. I’ve even tried freezing peanut butter inside, and that keeps them occupied even longer. Lick-style toys like this are great for slowing dogs down and keeping them calm and engaged.
It’s also been really helpful during times when I need a distraction—like when I’m busy, cleaning, or even during grooming.
Pros:
• Durable and holds up to chewing
• Can use peanut butter, yogurt, or other soft treats
• Keeps dogs busy for a long time
• Helps with boredom and anxiety
• Freezable for longer use
Cons:
• Can get messy depending on what you put in it
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Reviewed in the United States on April 2, 2026
★★★★★ 5
Hubie gives it two paws up !!
Hubie loves this he’s a Great Dane and a busy chewer.
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Reviewed in the United States on April 30, 2026
★★★★★ 1
My dog says no
Big block with a pattern on it...dog has absolutely no interest in it.
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Reviewed in the United States on April 9, 2026
★★★★★ 3
Doesn't hold their attention
I have 5 dogs, and only one of them seems to actually want to play with these toys, and even he's not that enthused. And he'll literally play with anything. I think it's the shape that's unappealing. My smallest sniffs and licks it, gives it a little nibble, hoping it will actually taste like peanut butter, but once he realizes it's just plastic he turns his nose up. They are solid, durable toys that should hold up to power chewers, but none of my power chewers care enough to bother for more than a few minutes. Size wise they're perfectly suited for the sizes intended.
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Reviewed in the United States on February 23, 2025
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