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Description
Fas Ligand/TNFSF6 His Tag Protein, MouseProduct Specification Species Mouse Synonyms CD95LFas ligandSPAFASLGSoluble Fas ligandsFasLReceptor binding FasL ectodomainFasL ICDTNFSF6Apoptosis antigen ligandTumor necrosis factor ligand superfamily member 6APLCD178Fas Ligand (TNF Superfamily Member 6)Fas Antigen LigandCD95 LigandCD95 LAPTLMutant Tumor Necrosis Factor Family Member 6Apoptosis (APO 1) Antigen Ligand 1CD178 AntigenALPS1BTNLG1AFasLFas Ligand ProteinSPPL2A processed FasL
Product Specification
| Species | Mouse |
| Synonyms | CD95L，Fas ligand，SPA，FASLG，Soluble Fas ligand，sFasL，Receptor-binding FasL ectodomain，FasL ICD，TNFSF6，Apoptosis antigen ligand，Tumor necrosis factor ligand superfamily member 6，APL，CD178，Fas Ligand (TNF Superfamily， Member 6)，Fas Antigen Ligand，CD95 Ligand，CD95-L，APTL，Mutant Tumor Necrosis Factor Family Member 6，Apoptosis (APO-1) Antigen Ligand 1，CD178 Antigen，ALPS1B，TNLG1A，FasL，Fas Ligand Protein，SPPL2A-processed FasL form，APT1LG1，Tumor Necrosis Factor (Ligand) Superfamily， Member 6，Tumor Necros，TNFSF6 |
| Accession | P41047-1 |
| Amino Acid Sequence | Pro132-Leu279, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 25-33kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Cell Death Differ . 2012 Jan;19(1):42-50. Epub 2011 Sep 30. |
Background
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigen-stimulated T cells. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include: T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
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4.3 ★★★★★
Based on 1093 reviews
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Product Reviews
★★★★★ 5
Highly Recommend to anyone going through family conflicts
Format: Hardcover
I love all of Nedra’s books. I highly recommend this book to anyone who has family conflicts that are taking a toll on them. It teaches you how to set proper boundaries and understand the situation and your feelings.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 25, 2026
★★★★★ 5
Practical Read for Managing Challenging Family Dynamics
Format: Hardcover
I found this text easy to read and a helpful way to reflect on my childhood experience and the relationships I have with my family members. The strategies are easy to implement.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 21, 2026
★★★★★ 5
Drama Free For Sure!
Format: Kindle
Nedra Glover Tawwab is a New York Times bestselling author, a licensed therapist, and a sought-after relationship expert. This book is a therapeutic and educational tool that addresses how to consciously change behaviors you’d rather not have in relationships, specifically, around your family. For those of us who have delved into the self-help book world, this is an in-depth, thorough refresher, focusing on family dynamics.
Nedra’s core belief is that relationships contribute to mental health. They can cause you pain or they heal you. She focuses on taking your relationships seriously and teaches the art of having tough but intentional conversations to create positive change. OR you’ll learn how to sever ties when the relationship is unmanageable.
None is more influential than the formative years we’ve had with our family of origin. A lot of people lament that not everything is about the family, but yup, so often it’s true. In childhood, most likely we weren’t allowed to be ourselves, so our true selves started to develop when becoming an adult. Like a butterfly using its colossal strength to break out of its chrysalis, we too must use our emotional colossal strength to break out of our childhood mold in order to fly. We are able to have relationships with family on our terms.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 11, 2023
★★★★★ 4
Insightful and Compassionate.
Format: Hardcover
I really love Nedra Glover Tawwab's work. I started with "Set Boundaries, Find Peace" and that opened the gateway to a broader and more helpful healing journey for me. This book, "Drama Fee" was just an evolutionary step in her series and a more in depth dealing with family relationships. The different perspectives for each chapter on how the concept can be applied was/is helpful as it often feels like books of this nature are only telling the black or white way to focus on a relationship. I felt seen and heard that though my familial relationships are unique there are commonalities and in turn ways to approach healing, reconciliation (with oneself and with family), understanding and compassion, to a achieve drama free relationships. As humans we are bread for connection and I appreciate Nedra Glover Tawwab's help in navigating them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 9, 2025
★★★★★ 5
Being Our True Selves In Relationships That Matter
Format: Kindle
Nedra Glover Tawwab is a New York Times bestselling author, a licensed therapist, and a sought-after relationship expert. This book is a therapeutic and educational tool that addresses how to consciously change behaviors you’d rather not have in relationships, specifically, around your family. For those of us who have delved into the self-help book world, this is an in-depth, thorough refresher, focusing on family dynamics.
Nedra’s core belief is that relationships contribute to mental health. They can cause you pain or they heal you. She focuses on taking your relationships seriously and teaches the art of having tough but intentional conversations to create positive change. OR you’ll learn how to sever ties when the relationship is unmanageable.
None is more influential than the formative years we’ve had with our family of origin. A lot of people lament that not everything is about the family, but yup, so often it’s true. In childhood, most likely we weren’t allowed to be ourselves, so our true selves started to develop when becoming an adult. Like a butterfly using its colossal strength to break out of its chrysalis, we too must use our emotional colossal strength to break out of our childhood mold in order to fly. We are able to have relationships with family on our terms.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 3, 2023
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